The Institute of Molecular and Cell Biology (IMCB) is a research institute under Singapore’s Agency for Science, Technology and Research (A*STAR). IMCB conducts fundamental and translational biomedical research across areas including neuroscience, cell biology, disease modelling and therapeutic discovery. The institute provides a collaborative environment with access to multidisciplinary expertise, advanced research platforms and partnerships across academia, healthcare and industry.

IMCB is recruiting a Scientist to develop and apply human induced pluripotent stem cell (iPSC)-based models to study glial cell biology in neurological and neurodegenerative diseases.

The role will focus on generating and characterising iPSC-derived glial cells, including astrocytes, microglia and oligodendrocyte-lineage cells, and applying these models to investigate disease mechanisms and therapeutic targets.

Key Responsibilities

• Generate and maintain human iPSC lines, include iPSC banking.
• Develop and optimise protocols for glial cell differentiation as well as neuronal cells.
• Establish disease-relevant cellular models, including co-culture or organoid systems.
• Perform molecular, imaging and functional assays to characterise glial phenotypes.
• Support the generation of genetically modified or isogenic iPSC lines using CRISPR or similar technologies.
• Analyse experimental data, including transcriptomic or single-cell datasets where relevant.
• Work with multidisciplinary teams across neuroscience, genomics, imaging and computational biology.
• Contribute to publications, research proposals and scientific presentations.
• Support junior researchers and maintain high standards of laboratory practice.

Job Requirements

• PhD in stem cell biology, neuroscience, cell biology, molecular biology or a related discipline.
• Experience in human pluripotent stem cell culture and differentiation.
• Experience with iPSC-derived neural or glial models is strongly preferred.
• Familiarity with astrocyte, microglial or oligodendrocyte biology would be advantageous.
• Experience with CRISPR, co-culture systems, imaging or single-cell analysis would be beneficial.
• Strong experimental, analytical and troubleshooting skills.
• Ability to work independently and collaboratively in a multidisciplinary research environment.