Long Description

Key Responsibilities

• Lead development and optimisation of GPCR functional assays, including reporter-based systems (e.g., luciferase, cAMP, calcium, β-arrestin readouts) suitable for medium- to high-throughput screening.
• Develop new reporter systems for additional functional or phenotypic endpoints beyond GPCR signalling.
• Design, generate, and validate stable or transient mammalian reporter cell lines, including construct design, molecular cloning, and cell line engineering.
• Collaborate with cross-functional teams (e.g., chemistry, computational biology, screening teams) to support compound evaluation and mechanistic studies.
• Analyse and interpret experimental data, including dose-response relationships, assay performance metrics, and screening outputs.
• Prepare scientific reports, presentations, and publications, and maintain rigorous documentation of experimental workflows.
• Supervise and train junior staff members, students, and interns.

Requirements

• PhD in Molecular Biology, Cell Biology, Synthetic Biology, Biochemistry, Pharmacology, or a related discipline.
• Strong hands-on experience in mammalian cell culture and cell line engineering, including transfection, selection, and maintenance of stable lines.
• Proven experience in designing and implementing reporter assays in mammalian systems (e.g., luciferase, fluorescent, or biosensor-based systems).
• Strong molecular biology and cloning skills, including construct design, vector systems, and DNA assembly techniques.
• Experience with GPCR biology and signalling pathways and/or assay formats used in GPCR screening is highly preferred.
• Demonstrated ability to independently design, execute, and troubleshoot experiments.
• Familiarity with assay development for screening applications, including optimisation of robustness and reproducibility
• Excellent communication skills and ability to work in a multidisciplinary team environment.