A postdoctoral research fellow position is currently available in our lab. The research will focus on investigate the tumor microenvironment, particularly myeloid cells in inflammation and cancer . We are interested in the deep immuno-profiling of these cells in cancer and immuno-metabolism, trying to characterize their immune signature and polarization state as well as use various in vitro tools and in vivo mouse models to dissect the underlying mechanism(s) to discover targets for modulating disease progression and testing tool compounds from collaborators. The work will be facilitated by excellent core service support in immunogenomics and high-dimensional immunophenotyping (e.g. CyTOF,luminex spatial immuno phenotyping). The project(s) will involve profiling of valuable patient cohorts, in vitro validation in cell culture systems and in vivo work in various preclinical animal models (e.g.tumor models).
· The interested candidate should either have a good knowledge of immunology (innate immune cells, T-cells) and/or of cancer microenvironment.
· Proficiency in flow cytometry-based immunophenotyping is an essential requirement, together with standard lab techniques like cell culture, qPCR and ELISA.
· Experience in handling and working with mice is required.
· Working with human samples models will be a bonus.
· The ability to analysis, interpret and present scientific results clearly to collaborators and for scientific communication is expected.
· The candidate should be motivated, able to perform research independently as well as a team player since the project involve clinical and industry collaborations.