The Genome Institute of Singapore (GIS) is Singapore's flagship institute for the genomic sciences. The Agency for Science, Technology and Research (A*STAR) is the parent funding body for the GIS and has a long-term commitment to advance science and develop innovative technology to further economic growth and improve lives. As one of the world's premier genomic centres, the GIS integrates genetics, genomics, high-throughput biology, and data science to gain fundamental, translational and clinical insights into human disease and health (https://www.a-star.edu.sg/gis/).
The GIS invites applications for outstanding Principal Investigators to develop their independent research programmes in the following domains:
Build technologies to engineer DNA or RNA (including molecular biology, viral/non-viral delivery, modified DNA/RNA, machine learning, CRISPR-Cas, DNAzymes/ribozymes, and other editing systems). Candidates with established track record in molecular engineering, nucleic acid therapeutics, translation into clinical trials, and/or biotech companies are highly desirable.
Build technologies in RNA therapeutics (including either using RNA as medicine or targeting RNA in diseases). Candidates with an established track record in targeting RNA or engineering RNA for protein production, decay, localization in health and disease systems are highly desirable.
Qualified candidates should have an MD, PhD or equivalent degree in the biological, genomic or computational sciences, and a demonstrated ability to conduct cutting-edge team-based research with a strong record of peer-reviewed publications, intellectual property creation, and external funding. You must be comfortable working in a dynamic research organisation and be able to balance multiple responsibilities. Strong communication skills and a willingness to work collaboratively in a multidisciplinary environment are critical for success. The successful candidate will drive an expansion into the indicated research areas and complement and synergise with ongoing research programmes at the GIS.