The Yu Lab has an opening position for Scientist recently and are looking for a highly motivated Scientist to join our team and contribute to innovative RNA-targeted therapeutic discovery.

We are a chemical biology lab dedicated to translational research targeting cellular nucleic acids. This project is to engineer antisense oligonucleotides (ASOs) for gene-selective regulation, paving the way for precision medicine. By leveraging cutting-edge gene-targeting strategies, structural biology, sequencing technologies, and computational approaches, we aim to unlock RNA as precise therapeutic target, addressing diseases linked to genomic dysregulation and undruggable pathways.

Contract length: 13-month contract for the first instance

Responsibilities:

• Lead the design and optimize RNA-targeting strategies in cells.
• Lead in designing and conducting experiments related to CRISPR, small-molecule screening, and ASO development.
• Perform molecular biology experiments, including CRISPR-based gene regulation, plasmid construction, stable cell line establishment, and RNA-seq library preparation.
• Maintain lab operations, including reagent preparation, consumable ordering, budget tracking, and equipment maintenance.
• Engage in literature reviews, research discussions, and collaborative projects.
• Ensure project milestones are met and contribute to manuscript preparation.

Requirements:

• PhD degree in Biological Sciences, Chemical Biology, or related fields.
• Experience in ASO design, molecular biology, cell culture, RNA biology, CRISPR, or sequencing technologies.
• Strong organizational skills and a positive, eager-to-learn attitude.
• Ability to work both independently and collaboratively in a fast-paced research environment.

Application Details

For inquiries or to apply, please email your CV and brief research interest to Zutao Yu (yuzt@a-star.edu.sg), with email title ?Scientist application_A*STAR?. More information about the lab can be found online: www.yucleiclab.com and https://www.a-star.edu.sg/gis/our-people/faculty-staff/members/yu-zutao .

Why Join Us?

The Genome Institute of Singapore (GIS), A*STAR is the national flagship program for genomic sciences in Singapore, with a mission to use genomics to improve public health and drive biomedical innovation. GIS offers a highly competitive remuneration package and relocation assistance. Singapore is a vibrant, cosmopolitan city-state at the heart of Asia, known for its excellent quality of life, world-class research infrastructure, and strong government support for scientific innovation.

Join us in advancing RNA and DNA-targeted therapeutics and making an impact in functional genomic medicine!