Key Responsibilities:
· Conduct Mendelian Randomization analyses to infer causal relationships between genetic variants and disease risk.
· Utilize and develop workflows using R for data analysis, including statistical modeling and visualization.
· Work with large-scale genomic datasets, including genome-wide association studies (GWAS), whole-genome sequencing (WGS), and polygenic risk scores (PRS).
· Perform survival analyses to examine genetic and epidemiological predictors of disease outcomes.
· Utilize DNAnexus or other cloud-based platforms for genomic data processing, storage, and computational workflows.
· Collaborate with multidisciplinary teams, including biostatisticians, clinicians, and geneticists, to interpret findings and drive translational insights.
· Publish findings in peer-reviewed journals and present at scientific conferences.
Job Requirements:
· A PhD (or equivalent) in Genetic Epidemiology, Bioinformatics, Biostatistics, Computational Biology, or a related field. Strong proficiency in Mendelian Randomization methods, including familiarity with MR-Base or other relevant tools.
· Expertise in R programming and experience with statistical packages (e.g., TwoSampleMR, survival, tidyverse, Bioconductor).
· Experience with handling and analyzing large genomic datasets, particularly GWAS, WGS, and PRS data.
· Experience with multi-ancestry genomic studies or integrating different omics datasets.
· Knowledge of genome-wide imputation methods and quality control procedures for genomic data.
· Exposure to machine learning approaches in genomics.
· Knowledge of survival analysis techniques (e.g., Kaplan-Meier, Cox proportional hazards models).
· Familiarity with DNAnexus or other cloud-based genomic analysis platforms is highly desirable.
· Strong analytical, problem-solving, and data visualization skills.
· Ability to work independently and collaboratively in a multidisciplinary research environment.
· Excellent written and verbal communication skills, with a track record of scientific publications.